Publications
Scientific papers
2022
Londoño PS, Serafini MR, Alves IA, Aragón DM. Recent Progress in Self-Emulsifying Drug Delivery Systems: A Systematic Patent Review (2011-2020). Crit Rev Ther Drug Carrier Syst. 2022;39(2):1-77
Ana Karla Bittencourt Mendes, Paola Miranda Sulis, Fernanda Carvalho Cavalari, Diana Patricia Rey Padilla, Marcela Aragón, Joana Margarida Gaspar, Fátima Regina Mena Barreto Silva. 1α,25-(OH)2 vitamin D3 prevents insulin resistance and regulates coordinated exocytosis and insulin secretion.The Journal of Nutritional Biochemistry, Volume 99, 2022,108864.
2021
Norman Urrego, Paula Sepúlveda, Marcela Aragón, Freddy A Ramos, Geison M Costa, Luis F Ospina, Leonardo Castellanos. Flavonoids and saponins from Passiflora edulis f. edulis leaves (purple passion fruit) and its potential anti-inflammatory activity, Journal of Pharmacy and Pharmacology, Volume 73, Issue 11, November 2021, Pages 1530–1538
E. Céspedes-Gutiérrez, D.M. Aragón, M.I. Gómez-Álvarez, J.A. Cubides-Cárdenas, D.F. Cortés-Rojas, Survival of the nematophagous fungus Duddingtonia flagrans to in vitro segments of sheep gastrointestinal tract, Experimental Parasitology, Volume 231,
2021,108172.
Elizabeth Céspedes-Gutiérrez,Diana M. Aragón-Novoa,Martha I. Gómez-Álvarez,Diego F. Cortés-Rojas. In vitro evaluation of physicochemical variables on the nematophagous fungus Duddingtonia flagrans. Journal of Basic Microbiolology 2021;1–10.
Marcela Aragón (editor). Passiflora ligularis Juss. (granadilla): estudios químicos y farmacológicos de una planta con potencial terapéutico. Ed., Universidad Nacional de Colombia, 2021,153p.
María I. Cardona, Gina P. Dominguez, Sandra M. Echeverry, Ivonne H. Valderrama, Andreas Bernkop-Schnürch, Marcela Aragón. Enhanced oral bioavailability of rutin by a self-emulsifying drug delivery system of an extract of calyces from Physalis peruviana, Journal of Drug Delivery Science and Technology 66 (2021) 102797.
Sandra M. Echeverry, Diana Rey, Ivonne H. Valderrama, Bibiana Verlindo de Araujo, Diana Marcela Aragón. Development of a self-emulsifying drug delivery system (SEDDS) to improve the hypoglycemic activity of Passiflora ligularis leaves extract, Journal of Drug Delivery Science and Technology 64 (2021) 102604.
Gina Paola Domínguez Moré, María Isabel Cardona, Paula Michelle Sepúlveda, Sandra Milena Echeverry, Cláudia Maria Oliveira Simões and Diana Marcela Aragón, Matrix Effects of the Hydroethanolic Extract of Calyces of Physalis peruviana L. on Rutin Pharmacokinetics in Wistar Rats Using Population Modeling, Pharmaceutics 2021, 13(4), 535.
C Guzmán, MA Rojas, M Aragón. (2021) Optimization of ultrasound-assisted emulsification of emollient nanoemulsions of seed oil of Passiflora edulis var. edulis. Cosmetics, 8(1):1
Norman Urrego, Paula Sepúlveda, Marcela Aragón, Freddy A. Ramos, Geison M. Costa, Luis F. Ospina and Leonardo Castellanos. Flavonoids and saponins from Passiflora edulis f. edulis leaves (purple passion fruit) and its potential anti-inflammatory activity,Journal of Pharmacy and Pharmacology, 2021, Vol XX, 1–9.
Monzón Daza G, Meneses Macías C, Forero AM, Rodríguez J, Aragón M, Jiménez C, Ramos FA, Castellanos L., (2021) Identification of α-Amylase and α-Glucosidase inhibitors and ligularoside A, a new triterpenoid saponin from Passiflora ligularis Juss (sweet granadilla) leaves, by a nuclear magnetic resonance-based metabolomic study. J. Agric. Food Chem., 69, 9, 2919–2931.
2020
Domínguez Moré, G.P., Feltrin, C., Brambila, P.F., Cardona, M.I., Echeverry, S.M., Simões, C.M.O. and Aragón, D.M., (2020) Matrix effects of the hydroethanolic extract and the butanol fraction of calyces from Physalis peruviana L. on the biopharmaceutics classification of rutin. J Pharm Pharmacol, 72: 738-747.
Diana Rey, Thaís Alves Fernandes, Paola Miranda Sulis, Renata Gonçalves, Michelle Sepúlveda R, Marisa Jádna Silva Frederico, Marcela Aragon, Luís Fernando Ospina, Geison M. Costa, Fátima Regina Mena Barreto Silva, (2020) Cellular target of isoquercetin from Passiflora ligularis Juss for glucose uptake in rat soleus muscle, Chemico-Biological Interactions,330,109198,
2019
Manuel Ibarra, Teresa Dalla Costa, Paula Schaiquevich, Rodrigo Cristofoletti, Ignacio Hernández González, Nicte S. Fajardo Robledo, Marcela Aragón Novoa, Marisín Pecchio, Ignacio Cortinez, Iñaki F. Trocóniz, Elba M. Romero-Tejeda. (2019) Iberoamerican Pharmacometrics Network Congress 2018 Report: Fostering M&S Approaches for Drug Development and Regulatory and Clinical Applications in Latin America., CPT Pharmacometrics Systems Pharmacology 8(4)197-200.
Paola A. Cárdenas, Álvaro Jiménez–Kairuz, Bibiana Verlindo de Araujo, Diana Marcela Aragón. (2019) Development of a dissolution method based on lipase for preclinical level A IVIVC of oral poly(e-caprolactone) microspheres. Journal of Drug Delivery Science and Technology, 52, 632-641.
Diana Rey, Paola Miranda Sulis, Thaís Alves Fernandes, Renata Gonçalves, Marisa Jádna Silva Frederico, Geison M. Costa, Marcela Aragón, Luís Fernando Ospina, Fátima Regina Mena Barreto Silva. (2019) Astragalin augments basal calcium influx and insulin secretion in rat pancreatic islets. Cell Calcium, 80 (1) 56-62.
Maria I. Cardona, Nguyet-Minh Nguyen Le, Sergey Zaichi, Diana M. Aragón, Andreas Bernkop-Schnürch. (2019) Development and in vitro characterization of an oral self-emulsifying delivery system (SEDDS) for rutin fatty ester with high mucus permeating properties. International Journal of Pharmaceutics, 562 (1) 180-186.
2018
Carlos-A. Bernal, Leonardo Castellanos, Diana M. Aragón, Diana Martínez- Matamoros, Carlos Jiménez, Yolima Baena, (2018) Freddy A. Ramos. Peruvioses A to F, sucrose esters from the exudate of Physalis peruviana fruit as a-amylase inhibitors., Carbohydrate Research (461) 4-10.
Jenny Alexandra Hernández-Rivera, Jorge Ariel Martínez-Ramírez, Maritza Rojas- Cardozo, Diana Marcela Aragón Novoa. (2018) Evaluation of Passiflora tripartita var. mollisima seed oil as potential nanoemulsion excipient., Journal Excipients and Food Chemistry (9) 16-27.
Allisson Jhonatan Gomes Castro, Luisa Helena Cazarolli, Lizandra C. Bretanha, Paola Miranda Sulis, Diana Patricia Rey Padilla, Diana Marcela Aragón Novoa, Betina Fernanda Dambrós, Moacir G. Pizzolatti, Fátima Regina Mena Barreto Silva. (2018) The potent insulin secretagogue effect of betulinic acid is mediated by potassium and chloride channels., Archives of Biochemistry and Biophysics (648) 20–26.
Sandra Milena Echeverry, Ivonne Helena Valderrama, Geison M. Costa, Luis Fernando Ospina-Giraldo, Diana Marcela Aragón. (2018) Development and optimization of microparticles containing a hypoglycemic fraction of calyces from Physalis peruviana., Journal of Applied Pharmaceutical Science, 8 (5) 010-018.
Sandra M. Echeverry, Hilbert I. Medina, Geison M. Costa, Diana M. Aragón. (2018) Optimization of flavonoid extraction from Passiflora quadrangularis leaves with sedative activity and evaluation of its stability under stress conditions., Brazilian Journal of Pharmacognosy 28 (5) 610-617.
Paula Sepúlveda, Geison M. Costa, Diana Marcela Aragón, Freddy Ramos, Leonardo Castellanos. (2018) Analysis of vitexin in aqueous extracts and commercial products of Andean Passiflora species by UHPLC-DAD., Journal of Applied Pharmaceutical Science 8 (09) 081-086.
2017
Paola A Cárdenas, Jadel M. Kratz, Aura Hernández, Geison M Costa, Luis Fernando Ospina, Yolima Baena, Cláudia M O Simões, Álvaro Jimenez – Kairuz, Marcela Aragón., (2017). In vitro intestinal permeability studies, pharmacokinetics and tissue distribution of 6-methylcoumarin after oral and intraperitoneal administration in Wistar rats, Brazilian Journal of Pharmaceutical Science., 53 (1): e16081
Maria I. Cardona, Reina M. Toro, Freddy A. Ramos, Leonardo Castellanos, Geison Costa, Marcela Aragón., (2017) Influence of extraction process on antioxidant activity and rutin content in Physalis peruviana calyces extract. Journal of Applied Pharmaceutical Science., 7 (6)164-168.
Gina Paola Domínguez Moré, Paola Andrea Cárdenas, Geison M. Costa, Cláudia M.O. Simões and Diana Marcela Aragón., (2017) Pharmacokinetics of Botanical Drugs and Plant Extracts. Mini-Reviews in Medicinal Chemistry, (17) 1646-1664.
2016
Paola Natalia Cáceres Guevara, Karen Luise Lang, Marcela Aragón Novoa., (2016). Cosmetovigilancia: un estudio de alcance. Rev. Colomb. Cienc. Quím. Farm., Vol. 45(2), 305-327.
Carlos-A. Bernal, Marcela Aragón, Yolima Baena., (2016). Dry powder formulation from fruits of Physalis peruviana L. standardized extract with hypoglycemic activity, Powder Technology., 301(1) 839–847.
2015
Geison Modesti Costa, Paola Andrea Cárdenas, Andressa Córneo Gazola, Diana Marcela Aragón, Leonardo Castellanos, Flávio Henrique Reginatto, Freddy Alejandro Ramos, Eloir Paulo Schenkel., (2015) Isolation of C-glycosylflavonoids with α-glucosidase inhibitory activity from Passiflora bogotensis Benth by gradient high-speed counter-current chromatography, J Chromatogr B Analyt Technol Biomed Life Sci. 15 (990):104-110.
Diana Patricia Rey, Luis Fernando Ospina, Diana Marcela Aragón., (2015). Inhibitory effects of an extract of fruits of Physalis peruviana on some intestinal carbohydrases. Rev. Colomb. Cienc. Quím. Farm., Vol. 44(1), 72-89.
Aura Rocío Hernández, Luis Fernando Ospina, Diana Marcela Aragón., (2015). Biodistribution study of free and microencapsulated 6-methylcoumarin in Wistar rats by HPLC, Biomedical Chromatography. 29 (1): 176 – 181.
Diana M. Aragón, Nadezdha E. Vergel, Luis F. Ospina, Jaiver E. Rosas, Fleming Martínez & Mario F. Guerrero., (2015) Enhanced Anticonvulsant Activity of Coumarin in Mice after its Microencapsulation in Eudragit® E100 Microparticles, Lat. Am. J. Pharm. 34 (10): 1920-1925.
2014
Paola A. Cárdenas Cuadros, Javier A. Barrera Alarcón, Aura R. Hernández Camargo, Luis F. Ospina Giraldo, Diana M. Aragón Novoa., (2014). Effect of 6- methylcoumarin-loaded polycaprolactone microparticles on carrageenan paw edema in rats, Lat. Am. J. Pharm. 33 (4): 550-556.
D.M. Aragón, J. E. Rosas And F. Martínez., (2014). Effect of the ibuprofen solubility in acetone and dichloromethane on the drug release profiles from PLGA microspheres, Latin American Applied Research. 44 (1): 87-92.
Reina M. Toro, Diana M. Aragón, Luis F. Ospina, Freddy A. Ramos and Leonardo Castellanos., (2014). Phytochemical analysis, antioxidant and anti-Inflammatory activity of calyces from Physalis peruviana, Natural Product Communication. 9 (11):1573-1575. DOI: